ODCs

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1 OMIM reference -
1 associated gene
3 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
5 signs/symptoms

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency

Pyogenic bacterial infections due to MyD88 deficiency


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	IRAK4	(0.89)	MYD88

Citations in the biomedical literature:

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency		Pyogenic bacterial infections due to MyD88 deficiency
	Synonym(s): - IRAK4 deficiency		Synonym(s): - MyD88 deficiency

	Classification (Orphanet): - Rare genetic disease - Rare immune disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: child / adolescent Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Immunodeficiency / increased susceptibility to infections / recurrent infections

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency		Pyogenic bacterial infections due to MyD88 deficiency
	Very frequent - Anomalies of the lymphatic system - Polynuclear cells / neutrophils anomalies / neutropenia		Very frequent - Autosomal recessive inheritance Frequent - Chronic skin infection / ulcerations / ulcers / cancrum - Nasal congestion / sinusitis / rhinitis / rhinorrhea Occasional - Fever / chilling